We are always looking for talented and enthusiastic new members fascinated by transposon and cancer biology. If you are interested in joining us, please send a CV, a description of your research interests and experience by e-mail to ozgendenizlab@gmail.com. Informal inquiries are welcome. See below for any specific adverts. We will also support candidates seeking to apply for postdoctoral fellowships to develop their own independent projects.
Postdoctoral Research Assistant 1
We are looking for a CRUK-funded Postdoc for fixed term appointment for 36 months, with possible extension and an expected start date of Spring/Summer 2023.
About You: Essential requirements for this post include a PhD (or be close to completion) in Molecular Biology, Life Sciences or a related discipline and an undergraduate degree in a biological subject. Significant research laboratory experience in general molecular and cellular biology techniques (qPCR, molecular cloning, mammalian cell culture) is essential. Experience in genomics techniques (ATAC-seq, ChIP-seq, CUT&RUN/CUT&Tag, RNA-seq), computational analyses of genomic data would be an advantage. A demonstrated ability to communicate well, work within a team and maintain good laboratory records are also essential. The post holder must be organised, highly self-motivated and have excellent communication and interpersonal skills. They will need to manage their time and performance, must be strongly proactive, knowledgeable, and able to solve complex problems. The post holder will be expected to prepare manuscripts using high-quality data, make oral presentations and help supervise postgraduate and graduate students.
About the project: A major area of CRUK-funded research in our lab is to investigate the oncogenic roles of transposable elements in acute myeloid leukaemia. To date, the search for oncogenic determinants has mainly focused on the non-repetitive genome and contributions from transposable elements have largely been ignored. Accounting for more than half of the human genome, transposable elements provide a rich source of cis-regulatory DNA sequences and can regulate cellular processes. Cancer cells provide epigenetically relaxed and permissive environments for their activation and therefore, transposable elements have the potential to be significant mediators of cancer progression. Combining CRISPR-based genome and epigenome editing with genomics analyses, we seek to understand how transposable elements are dysregulated in cancer and what consequences this has for the cancer cellular phenotype. By focusing on a previously understudied but important part of the genome, we hope to provide novel insights into cancer biology and uncover new determinants of oncogenic regulators that will contribute to development of new strategies in cancer therapies.
The project employs state-of-the-art molecular and cellular biology techniques, including ATAC-seq, ChIP-seq, CUT&RUN/CUT&Tag, RNA-seq (single-cell and bulk levels), oxBS-seq, PCHi-C; high throughput CRISPRi/a screens; CRISPR-mediated genetic and epigenetic editing in cell lines and primary cancer cells.
How to apply: Please follow the application link. The application deadline is 5th February. Informal inquiries are welcome!
Postdoctoral Research Assistant 2 (dry lab)
We are looking for a CRUK and BCI-funded Postdoc for fixed term appointment for 30 months, with possible extension and an expected start date of Autumn/Winter 2023. The research focus will be in the general area of regulatory genomics. The candidate will conduct independent research and development to integrate large scale epigenomics datasets to investigate the impact of transposable elements in cancer genomes. Please contact us for further information.
CRUK CoL Centre PhD studentship
A PhD studentship is available with an expected start date of Autumn 2023 to work on paediatric acute myeloid leukaemia. Funded by Cancer Research UK and Great Ormond Street Children Charity, this four-year version of the CRUK CoL Centre PhD studentship aims to overcome challenges to develop new therapies specifically for young patients. The deadline is 22nd March. Please apply through the application link and contact for further information.
Deniz lab 